One-pot synthesis of functionalized bis(trifluoromethylated)benziodoxoles from iodine(<scp>i</scp>) precursors
Tobias M. Milzarek, Nieves P. Ramirez, Xingyu Liu, Jérôme Waser
Abstract
Bis(trifluoromethylated)benziodoxoles (Bx) are broadly used cyclic hypervalent iodine reagents due to their stability and unique chemical properties. However, current methods to access them require several steps and long reaction times, making their synthesis tedious. Herein, a direct one-pot synthesis of bis(trifluoromethylated) Bx reagents from iodine(I) precursors is reported, enabling the synthesis of functionalized reagents.
Topics & Concepts
IodineChemistryCombinatorial chemistryOrganic chemistryOxidative Organic Chemistry ReactionsFluorine in Organic ChemistryCatalytic C–H Functionalization Methods