Improved Synthesis and Isolation of Bedaquiline
Hlengekile Lubanyana, Per I. Arvidsson, Thavendran Govender, Hendrik G. Kruger, Tricia Naicker
Abstract
)-BDQ. The advantages of this procedure are enhanced diastereoselection as well as a greener, faster way to achieve excellent enantioseparation (up to 1.0 g scale).
Topics & Concepts
BedaquilineDiastereomerAmideEnantiomerCombinatorial chemistryChemistryAmine gas treatingLithium amideChromatographyOrganic chemistryMycobacterium tuberculosisEnantioselective synthesisCatalysisTuberculosisMedicinePathologyTuberculosis Research and EpidemiologyCancer therapeutics and mechanismsPneumocystis jirovecii pneumonia detection and treatment