PKA Cα subunit mutation triggers caspase-dependent RIIβ subunit degradation via Ser <sup>114</sup> phosphorylation
Isabel Weigand, Cristina L. Ronchi, Jens T. Vanselow, Kerstin Bathon, Kerstin Lenz, Sabine Herterich, Andreas Schlösser, Matthias Kroiß, Martin Faßnacht, Davide Calebiro, Silviu Sbiera
Abstract
Mutations in PKA causative of adrenal Cushing adenomas increase cortisol secretion by triggering RIIβ subunit degradation.
Topics & Concepts
Protein subunitPhosphorylationMutationDegradation (telecommunications)SecretionChemistryMolecular biologyBiologyCell biologyBiochemistryGeneComputer scienceTelecommunicationsEndoplasmic Reticulum Stress and Diseaseinterferon and immune responsesCancer, Hypoxia, and Metabolism