Polymorphisms in Inflammatory Genes Modulate Clinical Complications in Patients With Sickle Cell Disease
Karina Tozatto‐Maio, Robert Girot, Indou Déme Ly, Ana Cristina Silva Pinto, Vanderson Rocha, Francisco Fernandes, Ibrahima Diagne, Yahia Benzerara, Carla Luana Dinardo, Júlia P Soler, Simone Kashima, Itauá Leston Araujo, Chantal Kenzey, Guilherme Henrique Hencklain Fonsêca, Evandra Strazza Rodrigues, Fernanda Volt, Luciana Ribeiro Jarduli, Annalisa Ruggeri, Christina Mary Mariaselvam, Sandra Gualandro, Hanadi Rafii, Barbara Cappelli, Felipe Melo Nogueira, Graziana Maria Scigliuolo, Renato Luiz Guerino-Cunha, Kelen Cristina Ribeiro Malmegrim, Belinda Pinto Simões, Éliane Gluckman, Ryad Tamouza
Abstract
= 0.049, in patients of same SCD genotype). These results, by uncovering susceptibility to, or protection against SCD complications, might contribute to a better understanding of the inflammatory pathways involved in SCD manifestations and to pave the way for the discovery of biomarkers that predict disease severity, which would improve SCD management.