Design, synthesis and biological evaluation of cinnamamide-quinazoline derivatives as potential EGFR inhibitors to reverse T790M mutation
Bin Zhang, Zichen Xu, Qingqing Liu, Shengjin Xia, Zhikun Liu, Zhi‐Xin Liao, Shaohua Gou
Topics & Concepts
ChemistryQuinazolineT790MMutantDocking (animal)EGFR inhibitorsProtein kinase BBiochemistryGefitinibEpidermal growth factor receptorApoptosisStereochemistryReceptorNursingMedicineGeneQuinazolinone synthesis and applicationsCancer therapeutics and mechanismsPeptidase Inhibition and Analysis