Synthesis of hydrazine containing piperazine or benzimidazole derivatives and their potential as α-amylase inhibitors by molecular docking, inhibition kinetics and in vitro cytotoxicity activity studies
Ümmühan Çakmak, Fulya Öz Tuncay, Serap Basoglu-Ozdemir, Elif Ayazoğlu Demir, İlke Demir, Ahmet Çolak, Selcen Çelik Uzuner, Safiye Sağ Erdem, Nuri Yıldırım
Topics & Concepts
ChemistryBenzimidazoleAcarboseADMEPiperazineCytotoxicityDocking (animal)In vitroAmylaseStereochemistryIn silicoCarbon-13 NMRCombinatorial chemistryProton NMRLead compoundSmall moleculeIC50BiochemistryEnzymeOrganic chemistryNursingMedicineGeneEnzyme Production and CharacterizationComputational Drug Discovery MethodsNatural Antidiabetic Agents Studies