Alarmins S100A8/A9 promote intervertebral disc degeneration and inflammation-related pain in a rat model through toll-like receptor-4 and activation of the NF-κB signaling pathway
Jinjian Zheng, Jianru Wang, Hui Liu, Fan Chen, Hongbin Wang, S. Chen, Julin Xie, Zhijie Zheng, Zhonghai Li
Topics & Concepts
InflammationS100A8TLR4Small interfering RNAAggrecanGene knockdownSignal transductionBlotDownregulation and upregulationTumor necrosis factor alphaImmunohistochemistryCell biologyNFKB1MedicineCancer researchBiologyImmunologyPathologyOsteoarthritisCell cultureTransfectionTranscription factorGeneBiochemistryGeneticsArticular cartilageAlternative medicineSpine and Intervertebral Disc PathologyS100 Proteins and AnnexinsSpondyloarthritis Studies and Treatments