Iridium(<scp>iii</scp>) complexes as mitochondrial topoisomerase inhibitors against cisplatin-resistant cancer cells
Liting He, Kai Xiong, Lili Wang, Ruilin Guan, Yu Chen, Liangnian Ji, Hui Chao
Abstract
Herein, we developed the first metal-based mitochondrial topoisomerase inhibitors to achieve an effective therapeutic outcome for the therapy of cisplatin-resistant tumour cells.
Topics & Concepts
CisplatinTopoisomeraseChemistryCancer cellIridiumMitochondrionBiochemistryCancerCancer researchEnzymeCombinatorial chemistryBiologyGeneticsChemotherapyCatalysisCancer therapeutics and mechanismsCancer Treatment and PharmacologyLung Cancer Research Studies