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Digital twins and Big AI: the future of truly individualised healthcare

Peter V. Coveney, Roger Highfield, Eric Stahlberg, Mariano Vázquez

2025npj Digital Medicine10 citationsDOIOpen Access PDF

Abstract

The integration of physics-based digital twins with data-driven artificial intelligence—termed “Big AI”—can advance truly personalised medicine. While digital twins offer individual ‘healthcasts,’ accuracy and interpretability, and AI delivers speed and flexibility, each has limitations. Big AI combines their strengths, enabling faster, more reliable and individualised predictions, with applications from diagnostics to drug discovery. Above all, Big AI restores mechanistic insights to AI and complies with the scientific method.

Topics & Concepts

Big dataHealth careData scienceComputer sciencePsychologyPolitical scienceData miningLawDigital Transformation in Industry
Digital twins and Big AI: the future of truly individualised healthcare | Litcius