Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease
Anna C. Riddell, Beatrix Kele, Kathryn Harris, Jon M. Bible, Maurice Murphy, Subathira Dakshina, Nathaniel Storey, Dola Owoyemi, Corinna Pade, Joseph M. Gibbons, David Harrington, Eliza Alexander, Áine McKnight, Teresa Cutiño‐Moguel
Abstract
The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is of public health concern in case of vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection in whom there is evidence of selection and persistence of novel mutations that are associated with increased transmissibility and immune escape.
Topics & Concepts
MedicineCoronavirusVirologyVirusImmunologyImmune systemRespiratory diseaseDiseaseLineage (genetic)Coronavirus disease 2019 (COVID-19)GeneBiologyInfectious disease (medical specialty)LungInternal medicineGeneticsSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesAnimal Virus Infections Studies