Radioligand Therapy in Metastatic Breast Cancer: Harnessing Precision Oncology
Federica Giugliano, Elisa Giordano, Laura Gilardi, Beatrice Taurelli Salimbeni, Paola Zagami, Angela Espósito, Antonio Marra, Dario Trapani, Pier Paolo Maria Berton Giachetti, Bianca Malagutti, Théophraste Henry, Désirèe Deandreis, Giuseppe Curigliano, Francesco Ceci, Carmen Criscitiello
Abstract
Radioligand therapy (RLT) represents a promising advancement in precision oncology and enables the targeted delivery of radiation to cancer cells. This approach has shown success in other tumor types, such as prostate cancer and neuroendocrine tumors. Its potential in metastatic breast cancer (mBC) is currently under investigation. This review discusses RLT mechanism of action, therapeutic potential, and integration into the existing therapeutic landscape of mBC. While clinical trials have shown promising results, challenges remain regarding target heterogeneity, implementation, and optimizing treatment strategies. Further research is essential to integrate RLT into clinical practice and improve patient outcomes fully.