MHC class II tetramers engineered for enhanced binding to CD4 improve detection of antigen-specific T cells
Thamotharampillai Dileepan, Deepali Malhotra, Dmitri I. Kotov, Elizabeth Motunrayo Kolawole, P. Krueger, Brian D. Evavold, Marc K. Jenkins
Topics & Concepts
Major histocompatibility complexAntigenStreptamerCD8MHC class IIT cellBiologyAntigen presentationMHC class ICell biologyAntigen-presenting cellMHC restrictionAlexa FluorFlow cytometryMolecular biologyChemistryImmune systemImmunologyNatural killer T cellFluorescencePhysicsQuantum mechanicsT-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune Cell Function and Interaction