Advances in the intraoperative delineation of malignant glioma margin
Shan Jiang, Huihui Chai, Qisheng Tang
Abstract
Surgery plays a critical role in the treatment of malignant glioma. However, due to the infiltrative growth and brain shift, it is difficult for neurosurgeons to distinguish malignant glioma margins with the naked eye and with preoperative examinations. Therefore, several technologies were developed to determine precise tumor margins intraoperatively. Here, we introduced four intraoperative technologies to delineate malignant glioma margin, namely, magnetic resonance imaging, fluorescence-guided surgery, Raman histology, and mass spectrometry. By tracing their detecting principles and developments, we reviewed their advantages and disadvantages respectively and imagined future trends.
Topics & Concepts
GliomaMedicineMagnetic resonance imagingMargin (machine learning)RadiologyComputer scienceCancer researchMachine learningSpectroscopy Techniques in Biomedical and Chemical ResearchGlioma Diagnosis and TreatmentNanoplatforms for cancer theranostics