Palladium catalyzed 8-aminoimidazo[1,2-<i>a</i>]pyridine (AIP) directed selective β-C(sp<sup>2</sup>)–H arylation
Biswajit Mondal, Prasanjit Ghosh, Mrinalkanti Kundu, Tapas Das, Sajal Das
Abstract
Palladium catalyzed arylation of the inert β-C(sp2)-H bond of carboxylic acid derivatives is reported herein for the first time utilizing 8-aminoimidazo[1,2-a]pyridine (AIP) as an efficacious and new inbuilt 6,5-fused bicyclic removable directing group. This protocol is scalable, exhibits high levels of β-site selectivity and tolerates a broad spectrum of functional groups.
Topics & Concepts
PalladiumCatalysisPyridineChemistryMedicinal chemistryStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCatalytic Cross-Coupling ReactionsSulfur-Based Synthesis Techniques