Association between the Non‐high‐Density Lipoprotein Cholesterol to High‐Density Lipoprotein Cholesterol Ratio and the Risk of Coronary Artery Disease
Jiayin You, Zhenhao Wang, Guoping Lü, Zhenyue Chen
Abstract
Background . The purpose of this study was to evaluate the association between the non‐high‐density lipoprotein cholesterol (non‐HDL‐C) to high‐density lipoprotein cholesterol (HDL‐C) ratio and the risk of coronary artery disease (CAD). We also explored the potential role of non‐HDL‐C/HDL‐C in the prognosis of CAD. Methods . We analyzed 930 consecutive patients with chest discomfort who underwent coronary angiography. Of these, 680 were diagnosed with CAD; the remaining 250 patients were normal. Multivariate logistic regression and receiver operating characteristic (ROC) curves were employed to evaluate the association between non‐HDL‐C/HDL‐C and CAD. The effect of non‐HDL‐C/HDL‐C on the progression of major adverse cardiovascular events (MACEs) was also explored. Results . Increased non‐HDL‐C/HDL‐C was associated with an increased risk of CAD (OR: 1.291; 95% CI: 1.039‐1.561; P = 0.013). The results of stratified analyses by CAD subtype showed a correlation between high non‐HDL‐C/HDL‐C and increased risk of acute coronary syndrome (OR: 1.661; 95% CI: 1.259‐2.207; P < 0.001), high Gensini score (OR: 1.408; 95% CI: 1.021‐1.935; P = 0.039), and multivessel disease (OR: 1.487; 95% CI: 1.128‐1.992; P = 0.007). Moreover, the areas under the ROC for the predictive value of non‐HDL‐C/HDL‐C for CAD, acute coronary syndrome, high Gensini score, and multivessel disease were 0.604, 0.658, 0.642, and 0.636, respectively. Non‐HDL‐C/HDL‐C in CAD patients was significantly correlated with the risk of long‐term MACEs ( P = 0.004). Conclusions . The findings of this study indicated that non‐HDL‐C/HDL‐C plays an important role in the risk and progression of CAD. These findings need verification by further large‐scale prospective studies.