The muscle reflex and chemoreflex interaction: ventilatory implications for the exercising human
Hsuan‐Yu Wan, Joshua C. Weavil, Taylor S. Thurston, Vincent P. Georgescu, Amber D. Bledsoe, Jacob E. Jessop, Michael J. Buys, Russell S. Richardson, Markus Amann
Abstract
Although the muscle reflex and the chemoreflex are recognized as independent feedback mechanisms regulating breathing during exercise, the ventilatory implications resulting from their interaction remain unclear. We quantified the individual and interactive effects of these reflexes during exercise and revealed differential modes of interaction. Importantly, the reflex interaction further amplifies the ventilatory response to exercise under hypoxemic conditions, highlighting a potential mechanism for optimizing arterial oxygenation in physically active humans at high altitude.
Topics & Concepts
ReflexBreathingMedicineAnesthesiaPhysical medicine and rehabilitationNeuroscience of respiration and sleepHeart Rate Variability and Autonomic ControlHigh Altitude and Hypoxia