Microglial Nrf2/HO-1 signaling gates remifentanil-induced hyperalgesia via suppressing TRPV4-mediated M1 polarization
Xiaowen Liu, Huamei Cai, Peng Liang, Hongli Ma, Yun Ju Yan, Weixia Li, Jing Zhao
Topics & Concepts
MicrogliaNeuroinflammationNeuroscienceDexmedetomidineHyperalgesiaChemistryTRPV4NeurochemicalAgonistSpinal cordPharmacologyMedicineNociceptionInflammationTransient receptor potential channelReceptorInternal medicinePsychologySedationPain Mechanisms and TreatmentsMusic Therapy and HealthMindfulness and Compassion Interventions