Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore
Jocelyn Qi-Min Teo, Cheng Yee Tang, Si Hui Tan, Hong Yi Chang, Sze Min Ong, Shannon Jing-Yi Lee, Tse-Hsien Koh, James Heng-Chiak Sim, Andrea Lay‐Hoon Kwa, Rick Twee‐Hee Ong
Abstract
In this study, we characterized carbapenem-resistant Klebsiella pneumoniae clinical isolates collected over a 12-year period in the largest public acute-care hospital in Singapore using whole-genome sequencing. The results of this study demonstrate significant genomic diversity with the presence of well-known epidemic, multidrug-resistant clones amid a diverse pool of nonepidemic lineages.
Topics & Concepts
Klebsiella pneumoniaeCarbapenemBiologyMultiple drug resistancePublic healthMicrobiologyKlebsiellaDrug resistanceMedicineGeneticsGeneAntibioticsEscherichia coliNursingAntibiotic Resistance in BacteriaEnterobacteriaceae and Cronobacter ResearchPlant Pathogenic Bacteria Studies