Maternal separation affects anxiety-like behavior beginning in adolescence and continuing through adulthood and related to Dnmt3a expression
Xiaobing Wang, Le Jiang, Wenhao Ma, Xiaoye Zheng, Ershu He, Bensi Zhang, Manoj Kumar Vashisth, Zhiting Gong
Abstract
Most anxiety disorders begin in adolescence and continue through adulthood, and research on adolescent anxiety's pathogenesis and treatment options is insufficient. In this research, our results show that maternal separation can successfully induce anxiety-like behavior in adolescent mice that continues through adulthood, further accompanied by abnormal expression of Dnmt3a, which provides an experimental basis for further development of anxiety/depression treatment programs more suitable for adolescence.
Topics & Concepts
AnxietyPsychologyHippocampusOpen fieldSeparation (statistics)Developmental psychologyClinical psychologyNeurosciencePsychiatryMachine learningComputer scienceEpigenetics and DNA MethylationNeuroendocrine regulation and behaviorChild and Adolescent Psychosocial and Emotional Development