Treatment of Wound Infections in a Mouse Model Using Zn <sup>2+</sup> -Releasing Phage Bound to Gold Nanorods
Huan Peng, Daniele Rossetto, Sheref S. Mansy, Maria C. Jordan, Kenneth P. Roos, Irene A. Chen
Abstract
strain resistant to polymyxins, a last-line antibiotic therapy. Unlike these antibiotics, the phage-nanomaterial showed no detectable toxicity or systemic effects in mice, consistent with the short duration and localized nature of phage-nanomaterial treatment. Our results demonstrate that phage therapy controlled by inorganic nanomaterials can be a safe and effective antimicrobial strategy in vivo.
Topics & Concepts
Phage therapyAntibioticsAntimicrobialMicrobiologyPseudomonas aeruginosaIn vivoPhotothermal therapyNanomaterialsBacteriophageAntibiotic resistanceBacteriaMaterials scienceChemistryBiologyNanotechnologyEscherichia coliBiotechnologyGeneGeneticsBiochemistryBacteriophages and microbial interactionsRNA Interference and Gene DeliveryNanoplatforms for cancer theranostics