An Agonistic Anti-CD137 Antibody Disrupts Lymphoid Follicle Structure and T-Cell-Dependent Antibody Responses
Jun Pyu Hong, Glennys V. Reynoso, Prabhakar S. Andhey, Amanda Swain, Jackson S. Turner, Adrianus C. M. Boon, Florian Krammer, Ali H. Ellebedy, Fabio Zanini, Maxim N. Artyomov, Heather D. Hickman, Michael Diamond
Abstract
T cells. Our experiments in mice suggest that agonistic anti-CD137 mAbs used in cancer and autoimmunity therapy may impair long-term antibody and B cell memory responses.
Topics & Concepts
CD137Germinal centerFollicular dendritic cellsBiologyAntibodyImmunologyCD8Monoclonal antibodyDendritic cellT cellAntigenCell biologyImmune systemB cellAntigen-presenting cellImmune Cell Function and InteractionImmunotherapy and Immune ResponsesT-cell and B-cell Immunology