Variability of Hydroxy-Itraconazole in Relation to Itraconazole Bloodstream Concentrations
Nathan P. Wiederhold, Ilan S. Schwartz, Thomas F. Patterson, George R. Thompson
Abstract
, 0.7838), and OH-ITZ levels were generally higher than ITZ levels (median OH-ITZ:ITZ ratio, 1.73; range, 0.13 to 8.96). However, marked variability was observed throughout the range of ITZ concentrations. Thus, it is difficult to predict OH-ITZ concentrations based solely on ITZ levels.
Topics & Concepts
ItraconazoleMedicineMicrobiologyBiologyAntifungalAntifungal resistance and susceptibilityFungal Infections and StudiesNail Diseases and Treatments