Hybrid Chemo-, Bio-, and Electrocatalysis for Atom-Efficient Deuteration of Cofactors in Heavy Water
Jack S. Rowbotham, Holly A. Reeve, Kylie A. Vincent
Abstract
H]-NADH recycling systems for driving reductive deuteration reactions, regardless of the facioselectivity of the coupled enzyme.
Topics & Concepts
ChemistryChemoselectivityCofactorNAD+ kinaseCombinatorial chemistryCatalysisElectrocatalystRedoxSelectivityIsotopic labelingBiocatalysisReductive eliminationEnzymeOrganic chemistryReaction mechanismElectrochemistryElectrodePhysical chemistryChemical Reactions and IsotopesAsymmetric Hydrogenation and CatalysisMass Spectrometry Techniques and Applications