Visible Light-Mediated Syntheses of γ-CF<sub>3</sub> Pyridines via 1,2-Radical Migration
Tingting Yuan, Xuan Deng, Xiaoyue Zhang, Zhen-Zhen Ruan, Zichen Xu, Ya‐Jian Hu, Yu‐Tao He
Abstract
An efficient method for the synthesis of γ-CF 3 pyridines via a visible light-mediated 1,2-radical migration strategy is presented. The overall process is thought to occur by the addition of a trifluoromethyl radical to allyl carboxylates, followed by 1,2-acyloxy migration and subsequent trapping with N -aminopyridinium salts.
Topics & Concepts
ChemistryTrifluoromethylTrappingVisible spectrumCombinatorial chemistryProcess (computing)PyridineOrganic chemistryRadicalYield (engineering)PhotochemistryCatalysisStereochemistryMoleculePolymer chemistryReaction conditionsFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques