Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System
John T. Loh, Miranda V. Shum, Scott D. R. Jossart, A. Malcolm Campbell, Neha Sawhney, W. Hayes McDonald, Matthew Scholz, Mark S. McClain, Mark H. Forsyth, Timothy L. Cover
Abstract
Helicobacter pylori encounters a wide range of pH within the human stomach. In a comparison of H. pylori cultured in vitro under neutral or acidic conditions, about 15% of genes are differentially expressed, and corresponding changes are detectable for many of the encoded proteins.
Topics & Concepts
RegulonBiologyTwo-component regulatory systemMutantResponse regulatorGeneHelicobacter pyloriBiochemistryGene expressionGeneticsHelicobacter pylori-related gastroenterology studiesMicrobial Metabolites in Food BiotechnologyGalectins and Cancer Biology