Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex
Kristina N. Schaefer, Mira I. Pronobis, Clara E. Williams, Shiping Zhang, Lauren Bauer, Dennis Goldfarb, Feng Yan, Michael B. Major, Mark Peifer
Abstract
embryos has paradoxical effects, promoting the ability of limiting levels of Axin to turn off Wnt signaling. When we elevate Dishevelled levels, it forms its own cytoplasmic puncta, but these do not recruit Axin. Superresolution imaging in mammalian cells raises the possibility that this may result by promoting Dishevelled:Dishevelled interactions at the expense of Dishevelled: Axin interactions when Dishevelled levels are high.
Topics & Concepts
DishevelledWnt signaling pathwayUbiquitin ligaseBiologyCell biologyUbiquitinEffectorSignal transductionFrizzledGeneticsGeneWnt/β-catenin signaling in development and cancerCancer-related gene regulationUbiquitin and proteasome pathways