Sialic Acid Derivatives Inhibit SiaT Transporters and Delay Bacterial Growth
Tiago Bozzola, Mariafrancesca Scalise, Christer Larsson, Michael C. Newton-Vesty, Caterina Rovegno, Ankita Mitra, Jonathan Cramer, Weixiao Yuan Wahlgren, Partha Radhakrishnan Santhakumari, Richard Johnsson, Oliver Schwardt, Beat Ernst, Rosmarie Friemann, Renwick C. J. Dobson, Cesare Indiveri, Jenny Schelin, Ulf J. Nilsson, Ulf Ellervik
Abstract
. This study represents the first example and a promising lead in developing sialic acid uptake inhibitors as novel antibacterial agents.
Topics & Concepts
Sialic acidChemistryTransporterBiochemistryBacteriaBacterial growthIn vitroBiologyGeneGeneticsAntibiotic Resistance in BacteriaBacteriophages and microbial interactionsVeterinary medicine and infectious diseases