Iron‐Catalyzed Cross‐Coupling Reactions for the Construction of Carbon‐Heteroatom Bonds
Juan Zhang, Siyu Wang, Yun Zhang, Feng Zhang
Abstract
Abstract Carbon‐heteroatom bonds are ubiquitous among pesticides, pharmaceutical agents, and natural products. In recent years, significant progress has been made in transition‐metal‐catalyzed carbon‐heteroatom bond formation. Especially, iron‐catalyzed reactions have become a focused area in organic chemistry owing to their advantages of low cost, economical and environmental benignity. This review intends to summarize the recent advances in the construction of carbon‐heteroatom bonds via cross‐coupling reactions using iron as a catalyst, including the formation of C−N, C−O, C−S, C−B, and C−Si bonds. A series of nucleophilic heteroatoms reagents, reaction classifications, and iron catalytic systems are discussed. In addition, some mechanistic studies have also been described.