CAVIN2/SDPR Functioned as a Tumor Suppressor in Lung Adenocarcinoma from Systematic Analysis of Caveolae-Related Genes and Experimental Validation
Keyun Zhu, Baichuan Wang, Yingxi Li, Yue Yu, Zhaohui Chen, Haoran Yue, Qingxiang Meng, Dongchen Tian, Xiaofeng Liu, Weiyu Shen, Yao Tian
Abstract
CAVIN2/SDPR functioned as a tumor suppressor, and was able to serve as prognostic biomarkers in precision medicine of LUAD. Mechanically, overexpression of CAVIN2/SDPR inhibited cell proliferation by inducing cell apoptosis and S phase arrest in LUAD cells.
Topics & Concepts
CaveolaeCarcinogenesisAdenocarcinomaCancer researchGene expression profilingCell cycleLung cancerMedicineGene expressionBiologyGenePathologyCell biologySignal transductionInternal medicineCancerGeneticsCaveolin-1 and cellular processesCancer-related molecular mechanisms researchCancer, Lipids, and Metabolism