Photosensitized 1,2-Difunctionalization of Alkenes to Access β-Amino Sulfonamides
Ze-Long Xiao, Zhenzhen Xie, Chu‐Ping Yuan, Ke-Yi Deng, Kai Chen, Hong‐Bin Chen, Hao‐Yue Xiang, Hua Yang
Abstract
A metal-free photosensitized 1,2-imino-sulfamoylation of olefins by employing a tailor-made sulfamoyl carbamate as the difunctionalization reagent has been established. This protocol exhibits versatility across a broad substrate scope, including aryl and aliphatic alkenes, leading to the synthesis of diverse β-imino sulfonamides in moderate to good yields. This method is characterized by its metal-free reaction system, mild reaction conditions, excellent regioselectivity, and high atom economy, serving as a promising platform for the preparation of β-amino sulfonamide-containing molecules, particularly in the context of drug discovery.
Topics & Concepts
ChemistryRegioselectivityReagentSulfonamideCombinatorial chemistryArylContext (archaeology)Substrate (aquarium)CarbamateAtom economyMoleculeOrganic chemistryCatalysisPaleontologyBiologyGeologyAlkylOceanographySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods