Biomimetic electrospun PVDF/self-assembling peptide piezoelectric scaffolds for neural stem cell transplantation in neural tissue engineering
Mahdi Forouharshad, Andrea Raspa, Giuseppe Fortino, Maria Gessica Ciulla, Arman Farazdaghi, Vlad Stolojan, Luca Stendardo, Silvia Bracco, Fabrizio Gelain
Abstract
studies showed that neural stem cells (NSCs) seeded on electrospun PVDF with additives exhibited desirable proliferation and differentiation compared to the gold standard. Furthermore, the orientation of the fibers influenced scaffold topography, resulting in a higher degree of cell orientation in fiber-aligned scaffolds compared to randomly oriented ones.
Topics & Concepts
PiezoelectricityNeural tissue engineeringTissue engineeringBiomimetic materialsMaterials scienceTransplantationNeural stem cellNanotechnologyBiomedical engineeringNeural cellStem cellCellChemistryComposite materialMedicineSurgeryCell biologyBiochemistryBiologyAdvanced Sensor and Energy Harvesting MaterialsNeuroscience and Neural EngineeringElectrospun Nanofibers in Biomedical Applications