The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions
Jinjun Chen, Lingyong Li, Shaorui Chen, Hong Chen, Jingdun Xie, Rita E. Sirrieh, David M. MacLean, Yuhao Zhang, Menghua Zhou, Vasanthi Jayaraman, Hui‐Lin Pan
Abstract
(Cell Reports 22, 2307–2321; February 27, 2018) In the originally published version of this article, an incorrect Input control blot, labeled as “Input: GFP” in Figure 3H, was inadvertently used. The corrected Figure 3 is shown here. This correction does not change the results and conclusions of this paper. The authors regret this error. The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic ActionsChen et al.Cell ReportsFebruary 27, 2018In BriefChen et al. show that α2δ-1, through its C terminus, physically interacts with NMDA receptors and promotes synaptic expression of α2δ-1-NMDA receptor complexes in neuropathic pain. Gabapentin reduces neuropathic pain primarily by targeting α2δ-1-bound NMDA receptors. Full-Text PDF Open Access