Electrochemical interface based on polydopamine and gold nanoparticles/reduced graphene oxide for impedimetric detection of lung cancer cells
Nguyen Dieu Linh, Nguyen Thi Trang Huyen, Nguyen Hai Dang, Benoı̂t Piro, Vũ Thị Thu
Abstract
self-polymerization of dopamine in an alkaline solution. The result has demonstrated the good adhesion and biocompatibility of polydopamine towards A-549 lung cancer cells. The presence of the two conductive materials (gold nanoparticles and reduced graphene oxide) has led to a six-times decrease in charge transfer resistance of polydopamine film. Finally, the as-prepared electrochemical interface was employed for impedimetric detection of A-549 cells. The detection limit was estimated to be only 2 cells per mL. These findings have proved the possibilities to use advanced electrochemical interfaces for point-of-care applications.
Topics & Concepts
GrapheneNanotechnologyOxideElectrochemistryMaterials scienceLung cancerColloidal goldNanoparticleChemistryMedicineElectrodePathologyMetallurgyPhysical chemistryAdvanced biosensing and bioanalysis techniquesGold and Silver Nanoparticles Synthesis and ApplicationsElectrochemical sensors and biosensors