The <i>Uppsala APP</i> deletion causes early onset autosomal dominant Alzheimer’s disease by altering APP processing and increasing amyloid β fibril formation
María Pagnon de la Vega, Vilmantas Giedraitis, Wojciech Michno, Lena Kilander, Gökhan Güner, Mara Zielinski, Malin Löwenmark, RoseMarie Brundin, Torsten Danfors, Linda Söderberg, Irina Alafuzoff, Lars Nilsson, Anna Erlandsson, Dieter Willbold, Stephan A. Müller, Gunnar F. Schröder, Jörg Hanrieder, Stefan F. Lichtenthaler, Lars Lannfelt, Dag Sehlin, Martin Ingelsson
Abstract
, accelerates the formation of fibrils with unique polymorphs and their deposition into amyloid plaques in the affected brain.
Topics & Concepts
Amyloid precursor proteinAlzheimer's diseaseAmyloid βDiseaseP3 peptideβ amyloidFibrilMedicineNeuroscienceBiologyPathologyGeneticsAlzheimer's disease research and treatmentsPrion Diseases and Protein MisfoldingNuclear Receptors and Signaling