Oxoammonium-Catalyzed Oxidation of <i>N</i> -Substituted Amines
Jonas Rein, Bartosz Górski, Yukun Cheng, Zhen Lei, Frédéric G. Buono, Song Lin
Abstract
We report the development of oxoammonium-catalyzed oxidation of N -substituted amines via a hydride transfer mechanism. Steric and electronic tuning of catalyst led to complementary sets of conditions that can oxidize a broad scope of carbamates, sulfonamides, ureas, and amides into the corresponding imides. The reaction was further demonstrated on a 100-g scale using a continuous flow setup.
Topics & Concepts
ChemistryCatalysisMedicinal chemistryOrganic chemistryCombinatorial chemistryOxidative Organic Chemistry ReactionsSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods