Differential and substrate-specific inhibition of γ-secretase by the C-terminal region of ApoE2, ApoE3, and ApoE4
Xianglong Hou, Xuexin Zhang, Huan Zou, Mingfeng Guan, Chaoying Fu, Wenyuan Wang, Zai-Rong Zhang, Yang Geng, Yelin Chen
Topics & Concepts
Terminal (telecommunication)Substrate (aquarium)Differential (mechanical device)NeuroscienceChemistryCell biologyAmyloid precursor protein secretaseBiologyBiochemistryBiophysicsInternal medicineAmyloid precursor proteinPhysicsMedicineComputer scienceAlzheimer's diseaseDiseaseTelecommunicationsEcologyThermodynamicsProtein Kinase Regulation and GTPase SignalingReceptor Mechanisms and SignalingComputational Drug Discovery Methods