Metabolic Promiscuity of an Orphan Small Alarmone Hydrolase Facilitates Bacterial Environmental Adaptation
Danny K. Fung, Kaihong Bai, Jin Yang, Xiaoli Xu, David Stevenson, Daniel Amador‐Noguez, Laixin Luo, Jue D. Wang
Abstract
displayed increased alarmone levels during starvation, loss of interspecies competitive fitness, growth defects, and strong reduction in NADH. Our findings reveal the importance of NADPH hydrolysis by a bacterial SAH. Our work is also the first report of significant physiological roles of bacterial SAHs beyond functioning as antitoxins and suggests that SAHs have far broader physiological roles and share similar functions across domains of life.
Topics & Concepts
Xanthomonas campestrisBiologyBiochemistryXanthomonas campestris pv. campestrisBacteriaEnzymeMutantMicrobiologyMetabolismCofactorGeneticsGenePolyamine Metabolism and ApplicationsPorphyrin Metabolism and DisordersAmino Acid Enzymes and Metabolism