Evaluation of nitrocatechol chalcone and pyrazoline derivatives as inhibitors of catechol-O-methyltransferase and monoamine oxidase
Rialette Hitge, Sharissa Smit, Anél Petzer, Jacobus P. Petzer
Topics & Concepts
ChalconePyrazolineChemistryEntacaponeCatechol-O-methyl transferaseMonoamine oxidaseIC50EnzymeEnzyme inhibitorStereochemistryBiochemistryPharmacologyLevodopaOrganic chemistryIn vitroParkinson's diseaseMedicineDiseaseGenePathologyAlleleSynthesis and Biological EvaluationParkinson's Disease Mechanisms and TreatmentsClick Chemistry and Applications