Sonogenetics: Recent advances and future directions
Tianyi Liu, Mi Hyun Choi, Jiejun Zhu, Tingting Zhu, Jin Yang, Na Li, Zihao Chen, Quanxiang Xian, Xuandi Hou, Dongmin He, Jinghui Guo, Chunlong Fei, Lei Sun, Zhihai Qiu
Abstract
Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.
Topics & Concepts
ClearanceComputer scienceKey (lock)Neural activityRisk analysis (engineering)NeuroscienceBiological neural networkArtificial intelligenceMachine learningPsychologyMedicineComputer securityUrologyUltrasound and Hyperthermia ApplicationsUltrasound and Cavitation PhenomenaUltrasound Imaging and Elastography