Litcius/Paper detail

Bacteriophage-driven microbial phenotypic heterogeneity: ecological and biogeochemical importance

Xiaolong Liang, Shuo Yang, Mark Radosevich, Yongfeng Wang, Ning Duan, Yongfeng Jia

2025npj Biofilms and Microbiomes24 citationsDOIOpen Access PDF

Abstract

Bacteriophages (phages) reprogram host metabolism and generate phenotypic heterogeneity, yet the mechanisms and ecological implications remain poorly understood representing a major knowledge gap in microbial ecology. This review explores how phage infection alters microbial physiology, contributes to single-cell variation, and influences population dynamics. We highlight the potential consequences of phage-driven heterogeneity for microbial community structure and biogeochemical cycling, underscoring the importance of integrating phage-host interactions into ecological and ecosystem models.

Topics & Concepts

Biogeochemical cycleBacteriophageEcologyBiologyMicrobial ecologyBacteriaGeneticsEscherichia coliGeneBacteriophages and microbial interactionsMicrobial Community Ecology and PhysiologyGenomics and Phylogenetic Studies