Origin of chemo- and stereoselectivity in NHC-catalyzed asymmetric intermolecular cycloadditions of hydrazone and isatin
Tingting Shen, Xinghua Wang, Ziyuan Zhou, Donghui Wei
Abstract
DFT was used to investigate the possible mechanisms of NHC-catalyzed asymmetric cycloadditions between hydrazones and isatins, including [4 + 2] and [3 + 2] cycloadditions.
Topics & Concepts
ChemistryHydrazoneStereoselectivityIsatinIntermolecular forceStereochemistryCycloadditionComputational chemistryDiastereomerPyrrolidineChiral auxiliaryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and Catalysis