FABP5 promotes lymph node metastasis in cervical cancer by reprogramming fatty acid metabolism
Chunyu Zhang, Yuandong Liao, Pan Liu, Qiqiao Du, Yanchun Liang, Shiyin Ooi, Shuhang Qin, Shanyang He, Shuzhong Yao, Wei Wang
Abstract
: Our findings highlight a FA metabolism-dependent mechanism of FABP5-induced LNM. Moreover, the expression and biological function of FABP5 can be regulated by miR-144-3p in hypoxia. Our study identifies FABP5 as a potential diagnostic biomarker and therapeutic target for LNM in CCa.
Topics & Concepts
ChemistryLymphangiogenesisDownregulation and upregulationFatty acid metabolismCancer researchFatty acid-binding proteinMetastasisFatty acidCancerInternal medicineMedicineBiochemistryGenePeroxisome Proliferator-Activated ReceptorsCancer, Lipids, and MetabolismCancer-related molecular mechanisms research