Construction of Atropisomeric 3-Arylindoles via Enantioselective Cacchi Reaction
Xiaojiao Li, Xiaojiao Li, Liujie Zhao, Zisong Qi, Xingwei Li, Xingwei Li
Abstract
The de novo construction of axially chiral 3-arylindoles bearing a C(3)–C(aryl) chiral axis has been realized by Pd-catalyzed enantioselective Cacchi reaction between aryl bromides and o-alkynylanilines. The reaction proceeded under mild conditions in high yields and excellent enantioselectivities.
Topics & Concepts
Enantioselective synthesisChemistryArylCatalysisAxial symmetryCombinatorial chemistryReaction conditionsOrganic chemistryMathematicsGeometryAlkylAxial and Atropisomeric Chirality SynthesisMolecular spectroscopy and chiralityNonlinear Waves and Solitons