Gasdermin family: a promising therapeutic target for cancers and inflammation-driven diseases
Danbin Wu, Yefei Chen, Yingxin Sun, Qing Gao, Bin Yu, Xijuan Jiang, Maojuan Guo
Abstract
This review focuses on current advances in researches of gasdermin family. The distinctive expression patterns and biological roles of members in this family were discussed. Most of them exhibit pore-forming activity on cell membranes and are executors for programmed cell death with cytokines release, and play roles in cancers and inflammation-driven diseases. Therefore, they can be used as potential therapeutic targets to treat related diseases.
Topics & Concepts
InflammationMedicineBioinformaticsImmunologyBiologyInflammasome and immune disordersToxin Mechanisms and ImmunotoxinsAutoimmune and Inflammatory Disorders Research