Persistent Circulating Severe Acute Respiratory Syndrome Coronavirus 2 Spike Is Associated With Post-acute Coronavirus Disease 2019 Sequelae
Zoe Swank, Yasmeen Senussi, Zachary Manickas-Hill, Xu G. Yu, Jonathan Z. Li, Galit Alter, David R. Walt
Abstract
The diagnosis of postacute sequelae of coronavirus disease 2019 (PASC) poses an ongoing medical challenge. To identify biomarkers associated with PASC we analyzed plasma samples collected from PASC and coronavirus disease 2019 patients to quantify viral antigens and inflammatory markers. We detect severe acute respiratory syndrome coronavirus 2 spike predominantly in PASC patients up to 12 months after diagnosis.
Topics & Concepts
MedicineCoronavirusCoronavirus disease 2019 (COVID-19)DiseaseSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)CoronaviridaeVirologyRespiratory diseaseRespiratory systemBetacoronavirus2019-20 coronavirus outbreakImmunologyInternal medicineOutbreakInfectious disease (medical specialty)LungLong-Term Effects of COVID-19SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies