Impact of Coronary CT Angiography–derived Fractional Flow Reserve on Downstream Management and Clinical Outcomes in Individuals with and without Diabetes
Gaurav S. Gulsin, Γεώργιος Τζίμας, Kenneth-Royce Holmes, Hidenobu Takagi, Stephanie Sellers, Philipp Blanke, Lynne Koweek, Bjarne Linde Nørgaard, J. Steen Jensen, Mark Rabbat, Gianluca Pontone, Timothy Fairbairn, Kavitha M. Chinnaiyan, Pamela S. Douglas, Whitney Huey, Hitoshi Matsuo, Niels Peter Rønnow Sand, Koen Nieman, Jeroen J. Bax, Tetsuya Amano, Tomohiro Kawasaki, Takashi Akasaka, Campbell Rogers, Daniel S. Berman, Manesh R. Patel, Bernard De Bruyne, Sarah Mullen, Jonathon Leipsic
Abstract
Purpose: To compare the clinical use of coronary CT angiography (CCTA)-derived fractional flow reserve (FFR) in individuals with and without diabetes mellitus (DM). Materials and Methods: This secondary analysis included participants (enrolled July 2015 to October 2017) from the prospective, multicenter, international The Assessing Diagnostic Value of Noninvasive CT-FFR in Coronary Care (ADVANCE) registry (ClinicalTrials.gov identifier, NCT02499679) who were evaluated for suspected coronary artery disease (CAD), with one or more coronary stenosis ≥30% on CCTA images, using CT-FFR. CCTA and CT-FFR findings, treatment strategies at 90 days, and clinical outcomes at 1-year follow-up were compared in participants with and without DM. Results: = .01). However, no between group differences were observed when stratified by stenosis severity (<50% or ≥50%) or CT-FFR positivity. Conclusion: See also the commentary by Ghoshhajra in this issue.© RSNA, 2023.