Evolution of Fluconazole Resistance Mechanisms and Clonal Types of <i>Candida parapsilosis</i> Isolates from a Tertiary Care Hospital in South Korea
Tae Yeul Kim, Hee Jae Huh, Ga Yeong Lee, Min Ji Choi, Hui‐Jin Yu, Sun Young Cho, Yun Sil Chang, Yae‐Jean Kim, Jong Hee Shin, Nam Yong Lee
Abstract
We investigated the evolution of fluconazole resistance mechanisms and clonal types of Candida parapsilosis isolates from a tertiary care hospital in South Korea. A total of 45 clinical isolates, including 42 collected between 2017 and 2021 and 3 collected between 2012 and 2013, were subjected to antifungal susceptibility testing, sequencing of fluconazole resistance genes ( ERG11 , CDR1 , TAC1 , and MRR1 ), and microsatellite typing.
Topics & Concepts
Candida parapsilosisFluconazoleTertiary careMicrobiologyEchinocandinsAntifungalResistance (ecology)Drug resistanceBiologyFungi imperfectiMedicineInternal medicineEcologyCaspofunginAntifungal resistance and susceptibilityFungal Infections and StudiesNail Diseases and Treatments