Disproportionation of Pharmaceutical Salts: pH<sub>max</sub> and Phase-Solubility/pH Variance
Alex Avdeef
Abstract
shift substantially in pH. The acid-base mass action model described here can be useful in predicting the stability of salt formulations in mixtures with excipients that can act as pH modifiers.
Topics & Concepts
DisproportionationSolubilityChemistryMolalityEutectic systemTitrationInorganic chemistryAqueous solutionSalt (chemistry)Base (topology)Solubility equilibriumActivity coefficientOrganic chemistryCatalysisAlloyMathematical analysisMathematicsCrystallization and Solubility StudiesChemical and Physical Properties in Aqueous SolutionsAnalytical Chemistry and Chromatography