Unveiling the role of polyphenols in diabetic retinopathy
Tapan Behl, Keshav Kumar, Sukhbir Singh, Aayush Sehgal, Monika Sachdeva, Saurabh Bhatia, Ahmed Al‐Harrasi, Camelia Liana Buhaș, Claudia Teodora Judea Pusta, Nicoleta Negruţ, Mihai Munteanu, Ciprian Brisc, Simona Bungău
Abstract
Diabetes retinopathy (DR) is the leading cause of blindness and is considered as the most ordinary microvascular complication of diabetes mellitus (DM). The current available therapies can only be effective in the progressive stages of DR and there are various clinical studies which depicts the inconclusive outcomes of these available therapies after assessing the long-term efficacy and safety of such treatments. Moreover, there is an indispensable need of a more reliable as well as potent treatment which can be considered as more efficacious treatment for the management of DR. The treatment of DR can be possible at the early stages with polyphenols which are plant derived chemical agents and can be act as an alternative to other treatments and can optimistically prevent the further evolution of disease. The present review emphasizes the role of polyphenols on cellular and molecular mechanisms altered by DR in preclinical and clinical studies.