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Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia

Pirro G. Hysi, Hélène Choquet, Anthony P. Khawaja, Robert Wojciechowski, Milly S. Tedja, Jie Yin, Mark Simcoe, Karina Patasova, Omar A. Mahroo, Khanh K. Thai, Phillippa Cumberland, Ronald B. Melles, Virginie J. M. Verhoeven, Véronique Vitart, Ayellet V. Segrè, Richard A. Stone, Nick Wareham, Alex W. Hewitt, David A. Mackey, Caroline C. W. Klaver, Stuart MacGregor, Peng T. Khaw, Paul J. Foster, Jeremy A. Guggenheim, Jugnoo S. Rahi, Eric Jorgenson, Christopher J. Hammond

2020Nature Genetics348 citationsDOIOpen Access PDF

Topics & Concepts

Refractive errorHeritabilityGenome-wide association studyBiologyGenetic associationMissing heritability problemGeneticsGeneBioinformaticsGenetic variantsEye diseaseGenotypeSingle-nucleotide polymorphismOphthalmology and Visual Impairment StudiesCorneal surgery and disordersRetinal Diseases and Treatments
Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia | Litcius